Symbol
Name
ID

Lepr
leptin receptor
MGI:104993

Phenotype annotations related to liver/biliary system

Darker colors indicate more annotations

Human Phenotypes	Hepatic steatosis	Micronodular cirrhosis	Subacute progressive viral hepatitis	Hepatocellular carcinoma
Disease(s) Associated with LEPR	Hepatic steatosis	Micronodular cirrhosis	Subacute progressive viral hepatitis	Hepatocellular carcinoma
hepatocellular carcinoma
metabolic dysfunction-associated steatotic liver disease

Mouse Phenotypes

increased hepatocyte apoptosis

enlarged liver

increased liver weight

increased liver glycogen level

decreased liver triglyceride level

increased liver triglyceride level

liver inflammation

hepatic steatosis

macrovesicular hepatic steatosis

microvesicular hepatic steatosis

increased susceptibility to diet-induced hepatic steatosis

liver fibrosis

Availability

Mouse Genotype

Lepr^db-9J/Lepr^db-9J

Lepr^db-lb/Lepr^db-lb

Lepr^db-Nokl/Lepr^db-Nokl

Lepr^db/Lepr^db

Lepr^m1Clo/Lepr^m1Clo

Lepr^m5Btlr/Lepr^m5Btlr

Lepr^m8Btlr/Lepr^m8Btlr

Lepr^{tm1b(EUCOMM)Wtsi}/Lepr^{tm1b(EUCOMM)Wtsi}

Lepr^tm1Jke/Lepr^tm1Jke

Lepr^db/Lepr^db-Nokl

Lepr^tm1.1Chua/Lepr^tm1.1Chua
Tg(Agrp-cre)1Gsb/0 (conditional)

Lepr^tm1Jke/Lepr^tm1Jke
Tg(Pomc1-cre)16Lowl/0 (conditional)

Lepr^tm1Rck/Lepr^tm1.1Rck
Tg(Syn1-cre)671Jxm/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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